RX features many default keyboard shortcuts to make editing and workflow easier. RX keyboard shortcuts can also be customized from the Edit|Preferences menu.

Default shortcuts:
| Keystroke (Windows/Mac) | Action |
| Ctrl/Command-O | file open |
| Ctrl/Command-W | file close |
| Ctrl/Command-S | file save |
| Ctrl/Command-shift-S | file save as |
| Ctrl/Command-shift-E | file export selection |
| Spacebar | play/stop |
| Return | return-to-zero |
| Ctrl/Command-L | toggle looping |
| Ctrl/Command-R | toggle playhead return |
| Ctrl/Command-F | toggle playhead follow |
| Ctrl/Command-shift-F | cycle playhead follow mode |
| Ctrl/Command-Z | undo |
| Ctrl/Command-Y | redo |
| Ctrl/Command-X | cut |
| Ctrl/Command-C | copy |
| Ctrl/Command-V | paste |
| Del | silence/delete |
| Ctrl/Command-A | select all |
| Ctrl/Command-comma | preferences menu |
| Alt-0 through 9 | show/hide processing modules |
| Ctrl/Command-0 through 9 | apply processing modules to the current selection |
| Alt-Shift-4 | train denoiser with current selection |
| Alt-r | show/hide spectrum analyzer panel |
| Ctrl-Shift-0 | toggle floating window opacity |
| Ctrl/Command-equals | zoom in |
| Ctrl/Command-hyphen | zoom out |
| Ctrl/Command-shift-hyphen | zoom out full |
| Ctrl/Command-\ | zoom selection |
| Ctrl/Command-[ | zoom left edge |
| Ctrl/Command-] | zoom right edge |
| F1 | help menu |